Targeted Molecular Therapies for NonMelanoma Skin Cancer
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چکیده
منابع مشابه
Targeted Molecular Therapies for Non-Melanoma Skin Cancer
EGFR is a transmembrane tyrosine kinase receptor of singling pathway that regulates proliferation, differentiation and apoptosis of cells and is involved in the pathogenesis and progression of different carcinoma types. The receptor may be targeted extracellularly by antiEGFR monoclonal antibodies such as cetuximab against the part of ligand-binding ectodomain or intracellularly by tyrosine kin...
متن کاملHereditary nonmelanoma skin cancer.
Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer predisposition, such as basal cell nevus syndrome, xeroderma pigmentosum, epidermo...
متن کاملNonmelanoma skin cancer.
Each year, there are as many cases of nonmelanoma skin cancer as all other cancers combined. Although there is relatively low attributable mortality, the morbidity and expense of treatment is significant. Unlike many other malignancies, host and environmental factors relevant to the pathophysiology have been clearly demonstrated. Surgical ablation remains the mainstay of treatment.
متن کاملTargeted Therapy in Nonmelanoma Skin Cancers
Nonmelanoma skin cancer (NMSC) is the most prevalent cancer in light-skinned populations, and includes mainly Basal Cell Carcinomas (BCC), representing around 75% of NMSC and Squamous Cell Carcinomas (SCC). The incidence of these tumors is continuously growing. It was found that the overall number of procedures for NMSC in US rose by 76%, from 1,158,298 in 1992 to 2,048,517 in 2006. Although mo...
متن کاملFacial resurfacing for nonmelanoma skin cancer prophylaxis.
OBJECTIVE To determine the effect of facial skin resurfacing for treatment of actinic keratoses (AKs) and prophylaxis against new primary basal and squamous cell carcinomas in individuals with previous nonmelanoma skin cancer (NMSC) or severe photodamage. DESIGN Randomized, prospective 5-year trial. SETTING Dermatology and otolaryngology clinics of a Veterans Affairs hospital. PATIENTS Th...
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ژورنال
عنوان ژورنال: SM Dermatology Journal
سال: 2015
ISSN: 2575-7792
DOI: 10.36876/smdj.1002